Caveolin-1 expression in odontogenic cysts and ameloblastomas.
نویسندگان
چکیده
OBJECTIVE The aim of this study is to evaluate the caveolin-1 expression in a group of odontogenic cysts and tumors. MATERIAL AND METHOD In this cross-sectional study, the expression of caveolin-1 was evaluated immunohistochemically in 75 samples including 18 cases of dentigerous cyst, 18 odontogenic keratocysts, 3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts and 34 ameloblastomas (solid and unicystic). RESULTS Positive immunohistochemical reaction was found in 100% of odontogenic cysts and this was significantly more than both unicystic (65%) and solid (55%) ameloblastomas. CONCLUSION The present study showed the expression of caveolin-1 in all odontogenic cysts and more than ameloblastomas. The results suggested that absence of caveolin-1 might enhance aggressiveness of odontogenic lesions and could be a useful marker for distinguishing ameloblastomas from other odontogenic lesions.
منابع مشابه
Angiogenesis: A Critical Role in Locally Aggressive Behavior of Keratocystic Odontogenic Tumor
Introduction: Odontogenic cysts are osteodestructive lesions affecting the jaws. Odontogenic keratocyst is an odontogenic cyst with highly aggressive features. Multicystic ameloblastoma is a benign epithelial odontogenic tumor with more aggressive behavior than dentigerous cyst and odontogenic keratocyst. Invasion and metastasis of tumors require increased blood vessels during tumorigenesis. Th...
متن کاملCaveolin-1 Expression in Odontogenic Cysts and Ameloblastomas Ameloblastom ve Odontojenik Kistlerde Caveolin-1 Ekspresyonu
Odontogenic cysts and tumors originate from remnants of odontogenic epithelium and have a wide spectrum of histopathologic and clinical characteristics, ranging from benign non-invasive to locally invasive or malignant lesions. Histopathologic similarities between these lesions may challenge the correct diagnosis, especially in small size specimens, and may also lead to unnecessary broad surger...
متن کاملImmunohistochemical comparative study of the odontogenic keratocysts and other odontogenic lesions.
OBJECTIVES The present study was undertaken to compare the pattern of expression of EGFR, cyclin D1, Ki-67, p-53 and carcinoembryonic antigen (CEA) in the epithelial lining of odontogenic keratocysts, dentigerous cysts, radicular cysts and ameloblastomas. METHODS four micrometers, formalin-fixed, paraffin-embedded tissue sections from 11 odontogenic keratocysts, 10 dentigerous cysts, 10 radic...
متن کاملThe role of RANK/RANKL/OPG signalling pathways in osteoclastogenesis in odontogenic keratocysts, radicular cysts, and ameloblastomas.
The aim of this study was to evaluate the immunohistochemical expression of molecules involved in osteoclastogenesis, including the receptor activator of nuclear factor kappa B (RANK), RANK ligand (RANKL) and osteoprotegerin (OPG) in odontogenic keratocysts (OKCs), which has been named as a keratocystic odontogenic tumour by the WHO, and compare their expression with radicular cysts and amelobl...
متن کامل[Correlations of extrocellular matrix metalloproteinase inducer and microvessel density to invasiveness of ameloblastoma].
BACKGROUND & OBJECTIVE Matrix metalloproteinases (MMPs) are involved in local invasion of ameloblastomas. This study was to evaluate the role of matrix metalloproteinase inducer (EMMPRIN) in angiogenesis in ameloblastomas by analyzing EMMPRIN expression and microvessel density (MVD) in ameloblastomas and odontogenic cysts. METHODS EMMPRIN expression and MVD in 41 specimens of ameloblastoma an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Turk patoloji dergisi
دوره 30 2 شماره
صفحات -
تاریخ انتشار 2014